Avid basketball fans, twins Robert and Raymond -- who start out at 381 and 378 pounds, respectively -- get the chance to meet players Kobe Bryant, Steve Nash, Byron Scott and James Worthy along their weight loss journey.

A tragic accident inspires a 399-pound firefighter to change his life; a 331-pound former college basketball player wants to overcome her depression and reclaim her life and her health.

Chris and Heidi help a formerly fit couple get back in shape for their wedding day; David Tutera, Rocco DiSpirito and Duff Goldman help the couples plan their big day.

A couple postpones their wedding so that they can lose weight. Their goal: to be able to wrap their arms around each other for their first dance.

Tiffany, an autism activist and single mother of an autistic teenager, battles her past history of eating disorders and negative food choices so she can live a longer life and continue to parent her son.

Born with a winning spirit, Rachel began dancing at three years old. As Rachel grew older, her spirit was hampered by mixed feelings towards love, sex and religion, so she turned to food for emotional support and became obese. Rachel is now looking to "get her groove back".

A former professional football player who weighs 531 pounds wants to get in shape before meeting the son he didn't know he had; a 313-pound camp counselor named Panda feels out of place in his adopted family.

Hannah, a successful career woman who weighs 310 pounds, seeks help after learning she is too heavy to have children; racing legend Mario Andretti makes a special appearance.

A 262-pound, 53-year-old woman who is also a hoarder is helped.

A one-time fit athlete, who added more than 100 pounds after her baby suffered brain damage from Shaken Baby Syndrome, hopes to lose her excess weight and, also, gather the strength to forgive the nanny who forever changed her and her child's lives.

Hannah, a successful career woman who weighs 310 pounds, seeks help after learning she is too heavy to have children; racing legend Mario Andretti makes a special appearance.