William lost his hair in a fire, but after years of bad hair pieces, Dr. Angie has a fix. Shanae suffers from bald spots and hopes Dr. Meena can do a transplant. Former model Charli is growing a beard, and it's up to Dr. Isha to help her save face.

Jamie has transitioned from male to female, but she needs Dr. Angie's help to leave her wigs behind; Neshia's body hair causes oozing sores, and she prays Dr. Meena can help; that he hopes Dr. Isha can remove.

Mir wants to ditch his comb-over for a full head of hair; Dr. Meena shows Allie her hair might not be so uncombable after all; Dr. Isha treats Raven's psoriasis and gives her some much-needed tough love.

Dr. Angie sees Holly, a patient with a deep, dark hair-related secret in need of help; Dr. Isha connects with single mom Vanh as she treats her pandemic-induced alopecia areata; Dr. Meena fights to help Devin keep his extreme body hair.

Dr. Angie treats Eva, a New Yorker who's gotten her long, flowing hair into a tangled and matted mess; Dr. Isha sees Gwen about a massive, confounding head growth; Dr. Meena meets Nellie, a Floridian with an unfortunate case of facial hair.

Dr. Angie treats Laura, a Canadian with an eyebrow-raising predicament; Dr. Isha gets a whiff of Brian, a patient suffering from smelly hair syndrome; Dr. Meena sees Sherri, a stressed-out single mom with a severe case of alopecia.