Heidi Klum returns to host twenty-two designers as they battle to win fashion's biggest prize. A jaw-dropping twist raises the stakes as the designers fight to secure a spot in the competition by presenting the judges with a signature look.

The designers have a second chance at a first impression as they are challenged to create a look that reflects their personal design style; in addition to the judges, the designers' fate will also be decided by some familiar faces.

The designers are divided into four fashion houses and challenged to create runway-worthy looks inspired by NFL teams; working together while maintaining their own creative voice proves to be difficult as emotions rise and bonds are tested.

In a series of head-to-head fashion battles, the designers create bold looks inspired by wild animals. Special guest models from Hulu's Get Real lineup bring the contestants' creations to life on the runway.

Creativity is put to the test when the designers must transform paper towels into high-fashion runway looks. The competition becomes personal when the designers must name who they believe is the weakest designer amongst them.

The designers compete for a coveted opportunity: creating a red-carpet look for Heidi Klum to wear at the premiere of The Devil Wears Prada 2. Glamour, elegance and high expectations collide.

The season 22 designers join forces to take on returning competitors from season 21 in the classic unconventional materials challenge. Familiar faces and unexpected materials create a high-stakes showdown.

Partnering with Dancing with the Stars, the designers create performance-ready fashions for some of the show's favorite professional dancers. Style and movement must work together seamlessly.