Ben Diskin

Nigel 'Numbuh 1' Uno / Hoagie Pennywhistle 'Numbuh 2' Gilligan Jr / Numbuh 101 (voice)

Lauren Tom

Kuki 'Numbuh 3' Sanban (voice)

Dee Bradley Baker

Wally 'Numbuh 4' Beatles / Mr. Fibb / Toilenator / Joaquin / Tommy Gilligan (voice)

Cree Summer

Abigail 'Numbuh 5' Lincoln / Former Numbuh 11 - Cree Lincoln (voice)

Jason Harris

Chad Dickson (voice)

Grey DeLisle

Crazy Old Cat Lady/Gramma Stuffum (voice)

Jeff Bennett

Mr. Boss / Mr. Fizz / Benedict Wigglestein (voice)

Jennifer Hale

Fanny 'Numbuh 86' Fulbright / Computer (voice)

Mark Hamill

Stickybeard (voice)

Tom Kenny

Knightbrace / Mr. Wink (voice)