In California conjoined twins Erika and Eva Sandoval undergo a 17-hour surgery. In Mississippi, Wells Middleton battles through his new future after losing both his hands. In Indonesia Andriadi Putra has over 30kg of tumors on his body

In Staten Island, New York, 15-year-old John suffers from epidermolysis bullosa and has no indication of how long he might live. In Kansas City, 28-year-old Justice suffers from a rare sleep condition called chronic neurological disorder.

After 22 surgeries and losing his right eye, Amit refuses to let his incurable neurofibromatosis define him. 9-year-old Rajeshwari seeks out medical help to deal with her Ichthyosis. Mari Jade suffers from daily fits.

Brandon's life changed forever when surgeons removed a large piece of his skull. Harper's rare condition means she makes skin 10 times faster. Rafi has embarked on an incredible journey from a devastating brain hemorrhage to a successful career.

In Madurai, India, Ravi receives life-changing surgery to remove the huge tumors that cover his face. In California, Lauren has 24-hour treatment to prolong her life.

Natalie suffered major, life-changing burns after a bonfire explosion. Now, aged 18, she's not letting her burns hold her back. In Mississippi, 11-year-old Levi has a rare form of dwarfism.

Natalie was born with a rare condition referred to as the 'vanishing bone disease'. Sanja has a condition that causes blisters to form on her skin. In Ohio, Tiffany, 41, was diagnosed with progeria when she was in her late twenties.

After having her leg amputated, Jillian has surgery which will allow her to use her ankle as her knee. In Peachtree City, USA, Ashley Kurpiel suffers from a rare condition that turns her muscles to bone.

The family of conjoined, twins, Callie and Carter, must decide whether to separate them. Abandoned by her birth mother and born with no arms, Deborah refuses to let her tragic early life hold her back. Josh shares his life as "The Tourette's Barber".

Both born with brittle bone disease, Dejua and Antwon have suffered over 600 breaks between them. Robert's spine is not connected to his hips. In California, Yesi, 35, was born with diastrophic dysplasia, a rare type of dwarfism.