Columbus' voyage is a success but a storm forces him to land on Portugal. The royals travel to Barcelona to sign a treaty with France, who ambitions to conquer Naples. The queen meets her new confessor, and her daughter ponders her future.

Columbus hides his doubts as he is pressed to make a second voyage. Portugal disputes the new lands to Castile, and France invades Italy. In Rome, the Pope juggles the rival countries interests for his own benefit.