A patient in Glasgow becomes violent, forcing crewmates Gregg and Bernadette to shelter in an ambulance. Meanwhile, paramedic Rebecca and technician Paige treat a life-threatening overdose.

Stevie and Pete of the Special Operations Response Team rescue a man suffering a mental health crisis. In Dunoon, paramedic Ben treats a man who has a blood clot in his lungs.

In Ayr, crewmates Sophie and Shelby treat a woman who is critically ill after a burst gastric ulcer. Meanwhile, Aberdeen paramedics care for a man with suspected meningitis.

Paramedics deploy to a large building fire in Glasgow City Centre, with concerns that people are trapped inside. Meanwhile, crewmates Sophie and Shelby face a difficult night shift in Ayr.

The Special Operations Response Team in Glasgow are deployed to a siege in a flat. Aberdeen crewmates Kirsty and Bruce treat a woman suffering a severe anaphylactic attack.

In a forest in East Ayrshire, paramedics struggle to treat a man who has suffered a traumatic injury in a mountain bike accident. Specialist equipment has to be brought in.