Dr. Koto's Clinic recounts the struggles of the young doctor Kensuke Goto who puts all his passion into medical treatment on one of Japan's distant islands while insisting on the preciousness of life. This is a brand new Dr. Koto installment with an episode involving another Dr. Koto: Shinichi Mikami.

A year has now passed since the arrival of the young physician Kensuke Goto (Dr. Koto) on Shikina Island, the southernmost island of the Japanese archipelago, the clinic he runs together with Ayaka and Wada is doing well. Ayaka's parents are now considering the possibility of Ayaka's marrying Dr. Koto, with the boss of the local fishermen involved in the situation.It's around this time that the island has its festival to pray for a good fishing catch, which results in several emergency cases at the clinic. After a very busy day at the clinic, Ayaka returns home, only to find that her mother has collapsed.