James Whitmore and newcomer Enzo Cerusico are partners in crimefighting in this laugh-accented drama series. They portray an unusual pair: John Woodruff, a criminology professor who does his teaching in the lab; and Tony, his fun-loving Italian friend whose boyish charm gets him in and out of the rough spots. Tonight: hired by Mayor Roy Muncie to set up a special criminology lab the two cross paths with the zealous new police commissioner who's determined to nail a syndicate boss--at any price. Complicating the situation is Tony's involvement with a girlfriend of the commissioner's.

Professor Woodruff is contacted by an old friend, Karen Walker, who is an alcoholic struggling to stay sober. When she threatens suicide, the professor and Tony must act fast.

Acting as investigators for an insurance company, Woodruff and Tony deduce that an ""accidental"" death was really murder. So why can't Woodruff get the police to take an interest in the matter?