After the events of season 4, Suntown became one of the most unsafe places to live. As a result, a large part of the population migrated to other cities, including Duny, Alex and Honey, who went to live in Rio de Fevereiro.

Duny, Honey and Alex receive a visit from Priscilão and Julie after a week of moving. The girls are excited about the reunion and several sudden events are a great potential for a huge mess.

On the 6th anniversary of "Girls In The House", Alex prepares to surprise Honey and Duny in celebration of their friendship, but not everything goes according to plan and the trio has to deal with the craziest unforeseen events.

The girls welcome back their dear friends but the surprise arrival of a relative will cause a lot of confusion on the eve of the opening of the new boarding house.

The girls visit Alex's family on a long trip to Ilhinha. During the visit, they discover that preparations for the June festival are underway in the city amid a family threat.

The girls are getting ready to open their new boarding house: Garotas Na Casa. A day full of celebrations will have unexpected surprises and unfortunately for them, not everything will be so positive.

The girls end up in trouble after gossiping while dealing with the arrival of new guests. Duny breaks her promise to Honey and does a compromising investigation.

Duny plans the ultimate revenge on her greatest enemies. While Alex enjoys an unusual day at the Spa, Honey helps Stacy at work and gets an unpleasant surprise.

Julie enlists Duny and Alex's help with her latest fashion project while Honey begins to suspect that she may not be the person she always thought she would be.

Honey, Alex and Duny organize the Embucete gender reveal party but do not expect the revelations that will happen at the event.

The girls will embark on a perilous adventure on the Devil's Trail to find Betina and make her pay for her crimes.