After the devastating bloodbath at the Lecter home, Hannibal establishes a new life for himself in Italy along with the company of his own psychiatrist, Bedelia.

With his wounds now healed, Will Graham heads to Europe eight months after the horrific event that almost took his life, in search of closure with Hannibal Lecter. Meanwhile, an Italian inspector suspects that Lecter and a killer he pursued 20 years earlier are the same person.

Will continues his search, making his way to Hannibal's childhood home in Lithuania. Meanwhile, Jack Crawford arrives in Italy, hoping to find Will and intervene before tragedy strikes again, and Bedelia warns Hannibal against unraveling his new life.

After surviving a disfiguring gunshot, Dr. Fredrick Chilton rallies support to capture Hannibal using Will as bait. Jack is distracted by Bella's failing health, but implores Will to abandon the risky idea of finding Hannibal. Meanwhile, Alana Bloom entertains a different approach, partnering with Mason Verger to utilize his vast resources.

Will travels via train with Chiyoh to Florence, as Alana and Mason use Hannibal's fine tastes to track his whereabouts. Pazzi tries to get in close to find out if Hannibal is the man he's looking for, but his greed may get the better of him.

With Bedelia securing her alibi, Hannibal prepares to leave Florence just as Jack and Will begin to track him down. However, Chiyoh has arrived in Florence with her own agenda.

Captured in Italy by police on Mason Verger's payroll, Will Graham and Hannibal Lecter are delivered to Muskrat Farm to await Mason's revenge.

Hannibal has been under lock and key for three years at the Baltimore State Hospital for the Criminally Insane when a new villain arises - Francis Dolarhyde, also known as "The Tooth Fairy." Crawford approaches Will to help catch the vicious serial killer targeting families.

Wading deeper into dangerous territory, Will enlists the help of Hannibal Lecter to assist with the search for an elusive serial killer. Elsewhere, a new woman comes into Dolarhyde's life.

Carvings symbolizing the Great Red Dragon shed light on Francis Dolarhyde's disturbing psychology. Will feels his bond with Hannibal growing uncomfortably stronger, and seeks out Bedelia Du Maurier, the only other person who fully understands the complexities of such a relationship.

Convinced that the Red Dragon will strike at the next full moon, Jack and Will grow desperate, and Alana turns to Hannibal for help.

Will enlists Dr. Frederick Chilton to lure Francis Dolarhyde into an ambush, using Freddie Lounds as their mouthpiece. Meanwhile, Dolarhyde senses that the FBI is closing in and launches a horrifying endgame.

In a desperate bid to slay Francis Dolarhyde, Will engineers a cunning ploy involving Hannibal.