Angela has a huge, melon-sized growth on the back of her neck that she fears will ruin her daughter’s wedding–and her daycare business. Loretta is terrified that her painful, oozing skin condition will get in the way of making her movie. Dr. Lee puts Dr. Tomassian’s experience to the test by letting him take the lead diagnosing a mysterious bump on Josh’s temple.

John is a sweet guy trying to get over his bumpy past, but not as bumpy as the huge growth on his shoulder. Tami has yellow deposits on her eyelids that make it impossible for her to feel beautiful.

Car lover Dave has 17 huge, painful head bumps that concern his girlfriend and make him feel like a freak. Melissa recently moved to a new town but her mysterious red, scaly lesions cover her legs and steal her confidence.

Jeana has huge, spherical growths dangling from her ears and the embarrassment is ruining her life. Alondra owns a flower shop but her painful, hydrangea-sized back bump prevents her from helping customers.

Tana deals with an abusive past, and a forehead bump has destroyed her food truck business aspirations. Vernestine, a die-hard Yankees fan, has a huge, misshapen growth on her back– but her kidney disease may prevent her from getting it removed.

John is bound to a wheelchair and ready to give up after his legs have become too swollen, painful, and smelly to enjoy a fulfilling life. Chad’s painful, giant hip growth has kept him from living his passion as an agile roller skater.

Veronica has a huge mango-sized growth on her back. Thomas has a deep passion for cosplay but is too embarrassed to dress up due to the large bump on their head. Dr. Lyndsey returns to help Dr. Lee shape former golf pro Ken's lumpy, bumpy nose.

Candace is a singer and doula whose huge face bump is stealing her youth. Christian has ignored the terrifying growth hanging off his tush. Otito worries that the extreme, thickened skin on her hands and feet will end her dental career.

Dr. Tolson learns how to help Dr. Lee treat Mary Beth's bumpy, mysteriously-changing face lesions. Dr. Ortiz steps in to help Kathy, who has thousands of red dots on her body that keep her from confidently wearing a bathing suit.

Dr. Lee, occupational therapist, arrives to help re-train her body post-stroke. Justin arrives with a body-covering, angry rash. Dr. Lee can only observe as Dr. Farhang attempts to remove AJ's huge forehead bump.

As Dr. Lee continues to recover from her stroke, she calls in reinforcements from Montana — her old dermatology residency pal, Dr. Kristen Townley. She assists Dr. Lee to help Cashanna, who is so ashamed of the clusters of bumps covering her eyelids.

As she continues to recover from her stroke, Dr. Lee again enlists her Montana friend Dr. Kristen Townley to remove Paul’s concerning windpipe bump. The doctors also try to help Kellie, who has a large, possibly vascular lump on the side of her head.

Dr. Lee is cleared to perform surgery; as she continues to rehab, she and Montana surgeon Dr. Kristen Townley work together to help Brandi, whose huge back bump is hurting her mobility and her relationship with her new boyfriend Phillip.

Brittany's home and career life are in shambles since her nose and cheeks erupted with bright red, oozing bumps; Dr. Sheila Farhang joins Dr. Lee for a lesson on how to remove John's painful, inflamed cysts.

Dr. Lee is ready to take the lead on her first surgery since her stroke, with Dr. Townley now assisting. Quentin has a cantaloupe-sized bump on his tricep that is ruining his mechanic career and making his girlfriend miserable.

Craig fears the massive growth on his neck could prevent him from helping his sick mother. Gwen is covered in dry, itchy patches that are causing hair loss and devastating her confidence.

Sevyn Streeter visits Dr. Lee with her friend Rose, who is concerned an unsightly shoulder lump is ruining her modeling career. Jamie is a family man who fears his young daughter is growing something that matches his angry, huge neck growth.

Charming Justin feels the thousands of bumps covering his face and body ruin his chance to find love. Reclusive Gene's girlfriend is frustrated that he will only leave the house to watch trains due to the gigantic lump on his head.

Dr. Sandra Lee, also known as Dr. Pimple Popper, is ready to take her practice to the next level. Dr. Lee will be providing intimate self-shot footage of her life outside the office.

Dr. Lee expresses appreciation to her friend Dr. Kristen Townley. Matline has a passion for horseback riding, but a painful bump on her back could end her time in the saddle. Steph Tolev is concerned about a head bump.