Brent Simons

Alan Schoolcraft

Keith Ferguson

Megamind (voice)

Laura Post

Roxanne Ritchi (voice)

Josh Brener

Ol' Chum (voice)

Maya Tuttle

Keiko Morita (voice)

Adam Lambert

Machiavillain (voice)

Emily Tunon

Lady Doppler (voice)

Talon Warburton

Lord Nighty-Knight (voice)

Scott Adsit

Pierre Pressure (voice)

Chris Sullivan

Behemoth (voice)

Tony Hale

Mel / Mr. Donut (voice)