Seth, a proud gay man, is invaded by his uptight, homophobic sister, Amanda. She just shows up on his doorstep (with luggage) for the first time in 20 years after catching her husband having an affair with her best friend, Katherine.

Seth and Amanda fall quickly back into the pattern of quarreling siblings as Amanda takes over his bedroom. It seems to Seth that Amanda is way more upset about her "best friend" Katherine cheating on her than her husband.

Seth and Amanda's boozy, inappropriately sexy mother, Frances shows up in the middle of the night. She tries her best to be sympathetic to both her children's plights, but first a cocktail or three. Frances takes over Seth's bedroom leaving Seth and Amanda to share the sofa.

After some not so quality family time over morning mimosas, Frances finally takes Amanda off Seth's hands, freeing up Seth to go back to Plan A - the first overnight date with his beau, Beau. But Amanda isn't finished spoiling Seth's weekend just yet.

Amanda has her doubts that Beau is everything he pretends to be and is determined to find out the truth. Frances can't stand the thought of her kids having fun without her and shows up. She's so impressed with young and handsome Beau that just might just steal him.

Seth witnesses Amanda change into a completely different person when she meets his lesbian co-worker, Becca. Frances and Beau show up with a surprise announcement that may push Seth and Amanda over the edge.