Debi Derryberry

Jimmy Neutron / Alien Actress / Alien Woman (voice)

Rob Paulsen

Carl Wheezer/Mr. Wheezer/Mrs. Wheezer/Test Pilot/Announcer (voice)

Jeffrey Garcia

Sheen Estevez / Army Guard (voice)

Frank Welker

Goddard (voice)

Carolyn Lawrence

Cindy Vortex (voice)

Crystal Scales

Libby Folfax (voice)

Tim Allen

Meldar Prime (voice)

Alyssa Milano

April (voice)

Carlos Alazraqui

Sr. Estevez (voice)

Jeff Bennett

Gorlock #2 / Brain #1 (voice)