Season 1
Five Emmy Awards and a Tony Award make multi-talented Neil Patrick Harris the perfect star for this live one-hour show that is unlike any other currently on American television. Complete with stunts, skits, pranks, audience interaction, musical numbers, giveaways and unlimited surprises, this show proves that anything can happen, and it can happen to you. Based on the wildly popular British hit "Ant & Dec's Saturday Night Takeaway", the modernized variety show format and its fearless, multi-talented star will make for one of the best nights ever on TV week after week.
Reese Witherspoon
Reese Witherspoon serves as the celebrity guest announcer during the series premiere of this variety show hosted by Neil Patrick Harris, which features A-list stars, performances, stunts, comedy skits, mini game shows, audience giveaways and hidden camera pranks. Based on the British series "Ant & Dec's Saturday Night Takeaway."
Alec Baldwin
Emmy Award winner Alec Baldwin serves as this week's celebrity guest announcer.
Tyler Perry
Tyler Perry is this week's celebrity guest announcer.
Shaquille O'Neal
Guest announcer Shaq joins Neil for an evening full of fun, games and housewives, with special guests Gloria Estefan, Zachary Levi and Blue Man Group.
Jack Black
Guest announcer Jack Black plus Olympic Gold medalist Apolo Ohno, and journalists Matt Lauer and Savannah Guthrie.
Reba
Guest announcer Reba plus singer OMI, and actors Jesse Tyler Ferguson and Jane Krakowski.
Kelly Ripa
Guest announcer Kelly Ripa plus singer Ray Parker Jr. and journalist Meredith Vieira.
Kelsey Grammer
Guest announcer Kelsey Grammer, the Backstreet Boys perform, plus Olympic gold medalist Apolo Ohno.