Bonnie refuses to let her many dogs go outside, creating disgusting, unsanitary conditions in her home. Don's living conditions and life has worsened from acquiring thirty cats, so his wife now lives in their daughter's home.

Janice has acquired so many dogs and cats that her current husband stops supporting her, her health suffers, and her family has to intervene. After a difficult childhood, J.D. has developed an addiction to saving animals, which is ruining her relationship with Patty.

Robin has been taking in lots of pets and hoarding objects so much that her relationship with her husband suffers. She is depressed that her daughters are moving away from her. Lolette runs a cat shelter that has over 300 cats. Unfortunately, disease is spreading, so many of the cats are sick.

A newlywed turns her house into an animal rescue when her Marine husband is deployed to Afghanistan, while a man is trapped in his house by a growing pack of feral dogs. 20-year-old Lauren's new home is overrun by stray animals. Her Marine husband is coming home next month and he doesn't know that the dogs have destroyed the house. Jack has become a slave to the care of his 45 feral dogs. Wracked by depression, he slips deeper into despair, as his family grows concerned.

Two women feel compelled to rescue unwanted animals, while leading dramatically different lives. A mother spends tens of thousands of dollars in veterinary bills to care for her growing menagerie. A convenience store clerk is being driven to destitution by her house full of dogs, cats, pigs and a raccoon. In both cases, family members are deeply concerned that the situation has grown dangerously out of control.

A couple turns over their new house to 80 pet cats; a woman has a houseful of exotic birds.

A woman helps her father reclaim his home from his hoard of pet chickens; a waitress loses her job due to her collection of cats.

A deckhand's colleagues band together to help with his hoarding problem; a mother faces losing her teen daughter because of her animal addiction.